Connecting you with the University of Missouri’s innovative research and creative activityFostering the Future of Undergraduate Research
A visit with Ted Tarkow, Professor of Classical Studies & Associate Dean of Arts & Science
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How the Undergraduate Research Mentorship Program began
Individualized research programs
More on the program’s history
Funding for Undergraduate Research Mentorship fellows
Corinne Alinea - A Potential Role for Programmed Cell Death in the Formation of an In Vitro Neural Stem Cell Niche
Reconstruction of Free Energy Profiles from Fast Nonequilibrium Processes
Stress and the American Toad
Effect of Parental Intervention and Toddler Distress in Fear eliciting Situations
Valuation, Information, and Bidding in Real Estate Auctions
Classifying Cicero’s Catilinarians
Seismic Station Installation in Isparta, Turkey and Surrounding Regions
Embryonic stem cells cross-correct for defects found in a mutant mouse model for the neurodegenerative disorder known as Batten Disease
Altered Nuclear Gene Expression in Response to Mitochondrial Mutations in Maize
Autonomy, Uncertainty, and Brute Luck Egalitarianism
Clean Cells, Liberating Prisons?: American and British Housewives after World War II and Women of Today
Clarifying Prehistory
Effects of Endocrine Disrupters on the Zebrafish Embryo
The Benefits of Online Emotional Disclosure
Synthesis of an Analog of the Novel Anti-neoplastic Agent Leinamycin
Topics:
antibiotic
leinamycin
Andrea Hicks, Chemistry
Kent Gates, Mentor
Leinamycin is a potent anti-tumor antibiotic that was isolated from a culture of Streptomyces in 1989. The unique compound features a 1,2-Dithiolan-3-one 1-oxide heterocycle which can cause DNA damage through multiple pathways. Hydrolysis t ½ of previous leinamycin analogs containing only the 1,2-Dithiolan-3-one 1-oxide group was approximately two hours, as compared to twenty-seven hours for leinamycin. The purpose of this project is to synthesize the leinamycin analog. This compound will be used to investigate the effect of a leinamycin-like vicinal amide group on the hydrolysis half-life of the 1,2-dithiolan-3-one-1-oxide.