http://www.syndicatemizzou.org Fri, 09 Jan 2009 23:19:09 GMT en-us 40 Center for eResearch Connecting you with the University of Missouri’s innovative research and creative activity http://www.syndicatemizzou.org/images/logo.png 384 80 http://syndicatemizzou.org/resources/urm2006/ipod/URM-Hicks.m4v Education http://syndicatemizzou.org/resources/urm2006/ipod/URM-Hicks.m4v ####Andrea Hicks, Chemistry ####Kent Gates, Mentor Leinamycin is a potent anti-tumor antibiotic that was isolated from a culture of _Streptomyces_ in 1989. The unique compound features a 1,2-Dithiolan-3-one 1-oxide heterocycle which can cause DNA damage through multiple pathways. Hydrolysis t ½ of previous leinamycin analogs containing only the 1,2-Dithiolan-3-one 1-oxide group was approximately two hours, as compared to twenty-seven hours for leinamycin. The purpose of this project is to synthesize the leinamycin analog. This compound will be used to investigate the effect of a leinamycin-like vicinal amide group on the hydrolysis half-life of the 1,2-dithiolan-3-one-1-oxide. 3 Mon, 13 Nov 2006 16:29:19 GMT